Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells
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DOI: 10.1021/acs.jmedchem.2c00455
Abstract: Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues.… read more here.
Keywords: elastase; elastase activatable; neutrophil elastase; alkyl radicals ... See more keywords