Engineering of an Enzyme-Activatable Ratiometric DNA Nanosensor for Spatially Resolved pH Imaging in Ischemic Stroke.
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DOI: 10.1021/acs.analchem.5c05918
Abstract: Spatially resolved imaging of intracellular pH during ischemic stroke (IS) is critical for demarcating salvageable penumbral tissue and tracking lesion progression; however, engineering IS-specific pH sensors remains challenging. Herein, we engineered an apurinic/apyrimidinic endonuclease 1… read more here.
Keywords: ischemic stroke; spatially resolved; nanosensor; resolved imaging ... See more keywords