Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT).
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DOI: 10.1073/pnas.2213777120
Abstract: The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D… read more here.
Keywords: human keratinocytes; dsdna mimetic; activate nlrp1; poly ... See more keywords