Visible-Light-Mediated Radical Silyl-Oximation of Activated Alkenes Using tert-Butyl Nitrite and Silanes.
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DOI: 10.1021/acs.orglett.2c03644
Abstract: A metal-free radical 1,2-difunctionalization of activated alkenes with various silanes and tert-butyl nitrite is reported. The radical cascade occurs by light-promoted homolytic O-NO bond cleavage of tert-butyl nitrite and subsequent hydrogen atom abstraction by the… read more here.
Keywords: tert butyl; activated alkenes; butyl nitrite; silyl oximation ... See more keywords
Rh(III)-Catalyzed Diastereodivergent Spiroannulation of Cyclic Imines with Activated Alkenes.
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DOI: 10.1021/acs.orglett.7b02678
Abstract: Rh(III)-catalyzed [3 + 2] annulation of cyclic N-sulfonyl or N-acyl ketimines with activated alkenes has been realized, leading to the synthesis of spirocycles with three continuous stereogenic centers. This atom-economic reaction proceeded efficiently under mild… read more here.
Keywords: spiroannulation cyclic; catalyzed diastereodivergent; diastereodivergent spiroannulation; cyclic imines ... See more keywords
Visible-Light Photoredox-Catalyzed Hydroalkoxymethylation of Activated Alkenes Using α-Silyl Ethers as Alkoxymethyl Radical Equivalents.
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DOI: 10.1021/acs.orglett.8b02721
Abstract: A new neutral silicon-based traceless activation group (TAG) for visible-light photoredox-catalyzed hydroalkoxymethylation of alkenes is presented. This reaction involves in-situ-generated alkoxymethyl radical via single electron oxidation (SET) of α-TMS-substituted ethers, followed by subsequent conjugate addition… read more here.
Keywords: alkoxymethyl radical; light photoredox; visible light; activated alkenes ... See more keywords
Hydroamination of non-activated alkenes with ammonia: a holy grail in catalysis.
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DOI: 10.1039/c9cs00873j
Abstract: Alkyl amines represent an important class of chemicals with multiple applications in our daily life. Among the different routes to alkyl amines, the catalytic hydroamination of alkenes with amines is of high interest mainly because… read more here.
Keywords: catalysis; hydroamination non; activated alkenes; hydroamination ... See more keywords
Synthesis of hydroxyl-containing oxindoles and 3,4-dihydroquinolin-2-ones through oxone-mediated cascade arylhydroxylation of activated alkenes
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DOI: 10.1039/d0gc02205e
Abstract: Hydroxyl-containing compounds are highly value-added organic molecules, and the establishment of novel methodologies for their elaboration is a long-standing challenge in organic synthesis. Here the first oxone-mediated direct arylhydroxylation of activated alkenes was developed for… read more here.
Keywords: hydroxyl containing; hydroxyl; arylhydroxylation activated; activated alkenes ... See more keywords
Phosphine-catalyzed divergent domino processes between γ-substituted allenoates and carbonyl-activated alkenes
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DOI: 10.1039/d1sc06364b
Abstract: Highly enantioselective and chemodivergent domino reactions between γ-substituted allenoates and activated alkenes have been developed. In the presence of NUSIOC-Phos, triketone enone substrates smoothly reacted with γ-substituted allenoates to form bicyclic furofurans in good yields… read more here.
Keywords: divergent domino; substituted allenoates; catalyzed divergent; activated alkenes ... See more keywords