Stereoselective Aminoiodination of Activated Alkynes with Organoiodine(III) Reagents and Amines via Multiple-Site Functionalization: Access to Iodinated Enamines and N -Aryl Indoles
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DOI: 10.1002/ejoc.201801725
Abstract: A stereoselective aminoiodination of activated alkynes with PhI(OAc)2 and amines via multiple-site functionalization to afford (Z)diethyl 2-(diphenylamino)-3-iodomaleate derivatives with superior yields has been described. The key feature of this reaction is the incorporation of iodide… read more here.
Keywords: activated alkynes; stereoselective aminoiodination; amines via; via multiple ... See more keywords
Transformation of 2-methyl-1-phenylethynyl-1,2,3,4-tetrahydroisoquinoline by the action of activated alkynes
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DOI: 10.1007/s10593-018-2306-y
Abstract: Transformations of 2-methyl-1-phenylethynyl-1,2,3,4-tetrahydroisoquinoline resulting from the action of activated alkynes in trifluoroethanol and hexafluoroisopropanol were studied. In reactions with dimethyl acetylenedicarboxylate, 6-phenylethynyl-substituted benzazocines were prepared, while methyl 4-benzyl-5-(2-ethenylphenyl)-1-methyl-1H-pyrrole-3-carboxylate and benzo[d][3]-azacyclodeca[4,6,7]triene with the allene fragment, respectively,… read more here.
Keywords: methyl phenylethynyl; activated alkynes; phenylethynyl tetrahydroisoquinoline; action activated ... See more keywords
Visible-Light-Mediated Vicinal Difunctionalization of Activated Alkynes with Boronic Acids: Substrate-Controlled Rapid Access to 3-Alkylated Coumarins and Unsaturated Spirocycles.
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DOI: 10.1021/acs.orglett.2c04333
Abstract: A visible-light-mediated difunctionalization of activated alkynes with boronic acid is unveiled to synthesize 3-alkylated coumarins and unsaturated spiro-lactones. The substituent at the para-position of the aryl ring of aryl alkynoate plays a pivotal role in… read more here.
Keywords: alkynes boronic; alkylated coumarins; visible light; difunctionalization activated ... See more keywords
Electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides: access to functionalized coumarins or quinolinones
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DOI: 10.1039/c9gc02131k
Abstract: A direct electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides toward functionalized coumarins and quinolinones has been developed. read more here.
Keywords: electrochemical oxidative; cyclization activated; oxidative cyclization; diselenides disulfides ... See more keywords
Lewis Acid Mediated Synthesis of 4-Aminoquinoline Derivatives from 2-Aminobenzonitriles and Activated Alkynes via Aza-Michael and Annulation Reactions
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DOI: 10.1055/a-2368-8500
Abstract: An efficient methodology for the synthesis of highly diverse 4-aminoquinoline derivatives from activated alkynes and 2-aminobenzonitriles mediated by Lewis acid is described. The reaction proceeds via sequential aza-Michael addition/intramolecular annulation to afford highly substituted 4-aminoquinolines… read more here.
Keywords: lewis acid; synthesis; aminoquinoline derivatives; aza michael ... See more keywords