Cortical laminar tau deposits and activated astrocytes in Alzheimer’s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography
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DOI: 10.1038/srep45496
Abstract: Hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of Alzheimer disease (AD) pathology. We here aimed to visualize in vitro the distribution of tau deposits and activated astrocytes across the cortical layers in… read more here.
Keywords: deposits activated; tau; thk5117 deprenyl; disease ... See more keywords
Cardiac sympathetic afferent ablation to prevent ventricular arrhythmia complicating acute myocardial infarction by inhibiting activated astrocytes
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DOI: 10.1111/jcmm.17508
Abstract: Enhanced cardiac sympathetic afferent reflex (CSAR) contributes to ventricular arrhythmia (VA) after acute myocardial infarction (AMI). However, central regulation mechanisms remain unknown. The aim of this study was to investigate whether local cardiac sympathetic afferent… read more here.
Keywords: activated astrocytes; cardiac sympathetic; group; ami ... See more keywords
Spinal high‐mobility group box‐1 induces long‐lasting mechanical hypersensitivity through the toll‐like receptor 4 and upregulation of interleukin‐1β in activated astrocytes
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DOI: 10.1111/jnc.14812
Abstract: Intrathecal treatment with recombinant high‐mobility group box‐1 (rHMGB1) in naïve mice leads to a persistent and significantly decreased hind paw withdrawal threshold to mechanical stimuli, suggesting that spinal HMGB1 evokes abnormal pain processing. By contrast,… read more here.
Keywords: hmgb1; mechanical hypersensitivity; rhmgb1; hypersensitivity ... See more keywords
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE.
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DOI: 10.1172/jci.insight.155563
Abstract: Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory responses… read more here.
Keywords: eae; inflammasome activated; inflammasome activation; aim2 inflammasome ... See more keywords
Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
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DOI: 10.1186/s12974-019-1508-2
Abstract: BackgroundAstrocyte activation is a common pathological feature in many brain diseases with neuroinflammation, and revealing the underlying mechanisms might shed light on the regulatory processes of the diseases. Recently, soluble epoxide hydrolase (sEH) has been… read more here.
Keywords: immune responses; seh; stat3; activation ... See more keywords