In Vitro Generation of Stem Cell Memory-Like T Cells from Activated T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0266-9_11
Abstract: Adoptive T-cell therapy is an attractive strategy for cancer immunotherapy. The transfer of in vitro expanded tumor-associated antigen (TAA)-specific T cells from patients may effectively fight against the original tumor cells. The chimeric antigen receptor-engineered… read more here.
Keywords: stem cell; like cells; cell memory; activated cells ... See more keywords
Suppression of adenosine monophosphate-activated protein kinase selectively triggers apoptosis in activated T cells and ameliorates immune diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.038
Abstract: Deficient apoptosis of activated T cells can result in immunological disorders. Molecules associated with energy and metabolisms are suggested to be involved in pathogenesis of immune diseases, but remain uninvestigated. In the present study we… read more here.
Keywords: apoptosis activated; activated cells; monophosphate activated; adenosine monophosphate ... See more keywords
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.05.028
Abstract: A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting host autoimmunity. We investigated homeostatic control of self-activated T cells within unperturbed tissue environments by combining high-resolution multiplexed and volumetric imaging with computational… read more here.
Keywords: regulatory cell; local regulatory; feedback; activated cells ... See more keywords
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.054
Abstract: SUMMARY Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the neurokinin-1 receptor (NK1R), a GPCR that mediates Ca2+ flux… read more here.
Keywords: receptor; ca2 flux; efficient ca2; activated cells ... See more keywords
Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110583
Abstract: In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI… read more here.
Keywords: activated cells; ligand independent; taci; transmembrane domain ... See more keywords
Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.03.005
Abstract: γδ T cells are a unique population of lymphocytes that have regulatory roles in patients with chronic hepatitis B (CHB); however, their role in acute hepatitis B (AHB) infection remains unclear. Phenotype and function of… read more here.
Keywords: hepatitis; acute hepatitis; activated cells; cytotoxicity capacity ... See more keywords
Glutathione Primes T Cell Metabolism for Inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.03.019
Abstract: &NA; Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent cellular damage. We report that GSH is essential for T cell effector… read more here.
Keywords: metabolism; activated cells; gsh; activation ... See more keywords
Direct effects of interleukin‐8 on growth and functional activity of T lymphocytes
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.06.023
Abstract: Abstract CD3+ T‐lymphocytes were isolated from the normal donors by positive magnetic separation. Activation of the T cells with particles conjugated with antibodies to CD3, CD28 and CD2 molecules led to a marked increase in… read more here.
Keywords: production; activated cells; activation; cd4 cell ... See more keywords
CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102482
Abstract: Summary Clinically important broadly reactive B cells evolve during multiple infections, with B cells re-activated after secondary infection differing from B cells activated after a primary infection. Here we studied CD27highCD38high plasmablasts from patients with… read more here.
Keywords: cells mixed; cd27hicd38hi plasmablasts; infection; activated cells ... See more keywords
WT1-specific cytotoxic T lymphocytes induced by activated B cells as apc
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.352
Abstract: Background & Aim WT1 is highly expressed in many malignancies including leukemia and targeting WT1 as a Tumor Associated Antigen (TAA) in cancer immunotherapy is attractive. In this study, we induced WT1-specific cytotoxic T lymphocytes… read more here.
Keywords: activated cells; specific ctls; antigen; wt1 specific ... See more keywords
High-dose vitamin D in Addison's disease regulates T-cells and monocytes: A pilot trial.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition"
DOI: 10.1016/j.nut.2017.10.021
Abstract: OBJECTIVES On the basis of the immunomodulatory actions of vitamin D (VD), we investigated the effects of high-dose VD therapy over a 3 mo period on the immune response in patients with Addison's disease (AD). METHODS… read more here.
Keywords: trial; high dose; activated cells; addison disease ... See more keywords