Light-Activated Cyclic Nucleotide Phosphodiesterases
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.950
Abstract: The second messengers 3′,5′-cyclic adenosine monophosphate (cAMP) and cyclic 3′,5′-cyclic guanosine monophosphate (cGMP) mediate various biological responses like apoptosis, smooth muscle relaxation and vision. Cyclic-nucleotide-dependent processes have been analyzed with spatiotemporal resolution through optogenetics. In… read more here.
Keywords: cyclic nucleotide; light activated; phosphodiesterase; activated cyclic ... See more keywords
Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide–gated and ryanodine 2 channels
Sign Up to like & getrecommendations! Published in 2018 at "Heart Rhythm"
DOI: 10.1016/j.hrthm.2017.12.027
Abstract: Background Aging is associated with an increased incidence of atrioventricular nodal (AVN) dysfunction. Objective The aim of this study was to investigate the structural and functional remodeling in the atrioventricular junction (AVJ) with aging. Methods… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15088
Abstract: Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are encoded by four genes (HCN1–4) with distinct biophysical properties and functions within the brain. HCN4 channels activate slowly at robust hyperpolarizing potentials, making them more likely to be engaged… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization‐activated cyclic nucleotide‐gated channels
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14747
Abstract: To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca2+ handling and insulin secretion. read more here.
Keywords: activated cyclic; insulin secretion; hyperpolarization activated; cyclic nucleotide ... See more keywords
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023356
Abstract: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1-4) have been cloned, each having a unique expression profile and distinctive effects on neuronal excitability within… read more here.
Keywords: cyclic nucleotide; activated cyclic; nucleotide gated; hyperpolarization activated ... See more keywords
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00141
Abstract: Neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic, progressive, and age-associated neurological disorders characterized by neuronal deterioration in specific brain regions. Although… read more here.
Keywords: neurodegenerative diseases; activated cyclic; hcn channels; hyperpolarization activated ... See more keywords
Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.848540
Abstract: Cannabinoids are a broad class of molecules that act primarily on neurons, affecting pain sensation, appetite, mood, learning, and memory. In addition to interacting with specific cannabinoid receptors (CBRs), cannabinoids can directly modulate the function… read more here.
Keywords: hcn1; activated cyclic; hcn1 channels; hyperpolarization activated ... See more keywords
Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010519
Abstract: Dexmedetomidine is a selective α2-adrenoceptor agonist and appears to disinhibit endogenous sleep-promoting pathways, as well as to attenuate noradrenergic excitation. Recent evidence suggests that dexmedetomidine might also directly inhibit hyperpolarization-activated cyclic-nucleotide gated (HCN) channels. We… read more here.
Keywords: channel function; activated cyclic; hyperpolarization activated; cyclic nucleotide ... See more keywords