Tunable Activated Esters Enable Lysine-Selective Protein Labeling and Profiling.
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DOI: 10.1021/acs.analchem.4c02215
Abstract: Lysine residues on protein surfaces are abundant and often found in enzyme active sites, making them critical targets for studying undruggable proteins. However, the varied microenvironment surrounding lysine residues results in a wide range of… read more here.
Keywords: esters enable; activated esters; labeling profiling; tunable activated ... See more keywords
Membrane transport inspired hydrolysis of non-activated esters at near physiological pH.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04525c
Abstract: A positively charged micelle loaded with substrates was transported selectively to the reaction site (cathode) to promote the proximity and localization of the reactants (ester and hydroxide). The guided vehicular delivery coupled with electrolysis allows… read more here.
Keywords: esters near; hydrolysis non; activated esters; non activated ... See more keywords