Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201800148
Abstract: Cancer‐associated fibroblasts (CAFs) are a heterogeneous population of activated fibroblasts that constitute a dominant cellular component of the tumor microenvironment (TME) performing distinct functions. Here, the role of tumor‐derived exosomes (Exos) in activating quiescent fibroblasts… read more here.
Keywords: activated fibroblasts; colorectal cancer; exosomes derived; primary metastatic ... See more keywords
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-021-00624-4
Abstract: Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between CAFs and cancer cells is essential for tumor progression and aggressiveness. Cancer cells… read more here.
Keywords: activated fibroblasts; cell migration; cancer cell; cancer ... See more keywords
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Nature biomedical engineering"
DOI: 10.1038/s41551-021-00709-w
Abstract: Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury. Using fibroblasts from porcine aortic valves cultured on hydrogels… read more here.
Keywords: nuclear mechanosensing; chromatin remodelling; activated fibroblasts; persistently activated ... See more keywords
Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56039-0
Abstract: Non-alcoholic steatohepatitis (NASH), characterized by chronic inflammation and fibrosis, is predicted to be the leading cause of cirrhosis and hepatocellular carcinoma (HCC) in the next decade. Although recent evidence suggests the importance of fibrosis as… read more here.
Keywords: activated fibroblasts; gene expression; model; cancer ... See more keywords
Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018060644
Abstract: BACKGROUND Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be… read more here.
Keywords: expression; fibrosis; gene; activated fibroblasts ... See more keywords