Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
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DOI: 10.1002/ijc.32899
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer‐related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment… read more here.
Keywords: hepatocellular carcinoma; hscs; activated hscs; hepatic stellate ... See more keywords
Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection
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DOI: 10.1016/j.yexcr.2017.08.001
Abstract: &NA; Th17 cells are involved in liver fibrosis by activating hepatic stellate cells (HSCs). We aimed to investigate whether HSCs are able to regulate the function of Th17 cells and to determine the relevant mechanism.… read more here.
Keywords: th17 cells; activated hscs; th17; hepatic stellate ... See more keywords
NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation
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DOI: 10.1155/2018/1239143
Abstract: Background Bone marrow-derived mesenchymal stem cells (BMSCs) have blossomed into an effective approach with great potential for the treatment of liver fibrosis. The aim of this study was to investigate the underlying antifibrosis mechanisms by… read more here.
Keywords: signaling pathway; activated hscs; nadph oxidase; cell ... See more keywords
Hepatic Stellate Cells and Hepatocarcinogenesis
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DOI: 10.3389/fcell.2020.00709
Abstract: Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation, leading to… read more here.
Keywords: hcc; tme; activated hscs; hepatic stellate ... See more keywords
Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells
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DOI: 10.3390/biom13030448
Abstract: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) in the liver due to chronic injuries and inflammation. These injuries activate and transform quiescent hepatic stellate cells (HSCs) into proliferative myofibroblast-like cells, which are… read more here.
Keywords: peptide based; stellate cells; activated hscs; liver ... See more keywords