The receptor for activated C kinase 1 (RACK1) mediating immune response in thick shell mussel Mytilus coruscus
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.04.004
Abstract: ABSTRACT The receptor for activated C kinase 1 (RACK1) is a intracellular receptor for the protein kinase C family which mediates various biological processes. Here, a novel RACK1 gene termed Mc‐RACK1 was identified from thick… read more here.
Keywords: activated kinase; mytilus coruscus; receptor activated; rack1 ... See more keywords
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.07.009
Abstract: Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase-… read more here.
Keywords: p21 activated; activated kinase; podosomes mouse; kinase pak ... See more keywords
Arabidopsis thaliana and Oryza sativa receptor for activated C kinase 1 (RACK1) mediated signaling pathway shows hypersensitivity to oxidative stress
Sign Up to like & getrecommendations! Published in 2021 at "Plant Gene"
DOI: 10.1016/j.plgene.2021.100299
Abstract: Abstract Scaffold proteins regulate cellular mechanisms and phenotypic patterns through protein-to-protein interactions. Receptor for Activated C Kinase 1 (RACK1) is a highly conserved protein containing 40 amino acid repeats of tryptophan-aspartic acid dipeptides (WD-repeat). RACK1… read more here.
Keywords: rack1; stress; thaliana; receptor activated ... See more keywords
A computational approach to explore and identify potential herbal inhibitors for the p21-activated kinase 1 (PAK1)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1659855
Abstract: Abstract The oncogenic kinase PAK1 (p21-activated kinase 1) is involved in developing many diseases including cancers, neurofibromatosis, Alzheimer's disease, diabetes (type 2), and hypertension. Thus, it is thought to be a prominent therapeutic target, and… read more here.
Keywords: p21 activated; kinase pak1; kinase; explore identify ... See more keywords
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2106478
Abstract: Abstract p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4… read more here.
Keywords: mice; activated kinase; p21 activated; pak4 ... See more keywords
Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0168
Abstract: P21-activated kinase 1 (Pak1) signalling plays a vital and overall protective role in the heart. However, the phenotypes of Pak1 deficiency in the cardiac atria have not been well explored. In this study, Pak1 cardiac-conditional… read more here.
Keywords: cko mice; activated kinase; p21 activated; mice ... See more keywords
Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0285
Abstract: Evidence accumulated over the past decade suggests that p21-activated kinase 1 (PAK1) is a critical cardiac-protective signalling molecule. The present article provides an updated review of recent findings regarding the role of PAK1 in maintaining… read more here.
Keywords: targeting p21; activated kinase; kinase development; p21 activated ... See more keywords
p21 protein‐activated kinase 1 is associated with severe regressive autism, and epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Genetics"
DOI: 10.1111/cge.13618
Abstract: The p21‐activated kinase (PAK) family of proteins function as key effectors of RHO family GTPases in mammalian cells to regulate many pathways including Ras/Raf/MEK/ERK and Wnt/β‐catenin, amongst others. Here we report an individual with a… read more here.
Keywords: regressive autism; severe regressive; p21 protein; activated kinase ... See more keywords
Interactome analysis of transforming growth factor-β-activated kinase 1 in Helicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24544
Abstract: Transforming growth factor-β (TGFβ)-activated kinase 1 (TAK1) plays a central role in controlling the cellular pro-inflammatory response via the activation of the nuclear factor κB (NF-κB)- and mitogen-activated protein (MAP) kinases-dependent transcriptional programs. Here, we… read more here.
Keywords: transforming growth; cdc37; activated kinase; growth factor ... See more keywords
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.759259
Abstract: p21-Activated kinase-1 (Pak1) is frequently overexpressed and/or amplified in human breast cancer and is necessary for transformation of mammary epithelial cells. Here, we show that Pak1 interacts with and phosphorylates the Calcium/Calmodulin-dependent Protein Kinase II… read more here.
Keywords: activated kinase; kinase; breast cancer; calcium calmodulin ... See more keywords
The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1123784
Abstract: Although the identification of numerous genes involved in neurodevelopmental disorders (NDDs) has reshaped our understanding of their etiology, there are still major obstacles in the way of developing therapeutic solutions for intellectual disability (ID) and… read more here.
Keywords: neurodevelopmental disorders; basis p21; activated kinase; p21 activated ... See more keywords