p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01600-9
Abstract: Ewing sarcoma (ES) is the second most common bone tumor in children and young adults. Unfortunately, there have been minimal recent advancements in improving patient outcomes, especially in metastatic and recurrent diseases. In this study,… read more here.
Keywords: p21 activated; risk; high risk; activated kinases ... See more keywords
Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020462
Abstract: Over the last three decades, p21-activated kinases (PAKs) have emerged as prominent intracellular nodular signaling molecules in cancer cells with a spectrum of cancer-promoting functions ranging from cell survival to anchorage-independent growth to cellular invasiveness.… read more here.
Keywords: activated kinases; cancer therapeutic; kinases human; p21 activated ... See more keywords