Measurement of NF-κB Activation in TLR-Activated Macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_5
Abstract: Nuclear factor kappa-B (NF-κB) is a key transcription factor in the regulation of the innate immune inflammatory response in activated macrophages. NF-κB functions as a homo- or hetero-dimer derived from one or more of the… read more here.
Keywords: activation tlr; microscopy; activated macrophages; activation ... See more keywords
Anti-inflammatory mechanisms of neovestitol from Brazilian red propolis in LPS-activated macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.07.029
Abstract: Abstract Neovestitol is considered one of the main bioactive components of Brazilian red propolis. Neovestitol’s antimicrobial and antioxidant effects have already been demonstrated. Here, neovestitol immune modulatory effects were investigated on LPS activated macrophages. RAW264.7… read more here.
Keywords: red propolis; production; activated macrophages; lps activated ... See more keywords
Proangiogenic characteristics of activated macrophages from patients with age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.11.018
Abstract: Macrophages were previously implicated in the pathogenesis of neovascular age-related macular degeneration (nvAMD). It is unclear if a specific macrophage phenotype is associated with nvAMD, and if macrophages from nvAMD patients are more pathogenic as… read more here.
Keywords: macular degeneration; age related; activated macrophages; age ... See more keywords
TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111590
Abstract: Bacillus Calmette-Guérin (BCG)-activated macrophages (BAMs) have anti-tumor effects, especially on fibrosarcoma cells. However, the mechanism governing this process has not been elucidated to date. TRIM59 is an up-regulated membrane protein expressed on the surface of… read more here.
Keywords: activated macrophages; trim59; bacillus calmette; fibrosarcoma cells ... See more keywords
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4316
Abstract: Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinephrine (NE). NE enhances thermogenesis through… read more here.
Keywords: activated macrophages; tissue; alternatively activated; adipose tissue ... See more keywords
Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64431-4
Abstract: Advances in microbiome research suggest involvement in chronic inflammatory diseases such as rheumatoid arthritis (RA). Searching for initial trigger(s) in RA, we compared transcriptome profiles of highly inflamed RA synovial tissue (RA-ST) and osteoarthritis (OA)-ST… read more here.
Keywords: activated macrophages; synovial tissue; gene patterns; rheumatoid arthritis ... See more keywords
β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12536
Abstract: Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at… read more here.
Keywords: recognition; glucan receptors; hookworm; larvae ... See more keywords
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci83626
Abstract: Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays a crucial role in controlling energy metabolism through central and… read more here.
Keywords: energy; activated macrophages; alternatively activated; cannabinoid receptor ... See more keywords
Transcriptional Characteristics of Activated Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/1381612825666190319120132
Abstract: Macrophages are key players in human innate immunity that protect the organism from pathologic agents, including infection and malignant cells. The spectrum of their functions includes initiation and maintaining of inflammation, cleaning of pathogens and… read more here.
Keywords: activated macrophages; biology; macrophage; characteristics activated ... See more keywords
Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.936167
Abstract: In the lungs, macrophages constitute the first line of defense against pathogens and foreign bodies and play a fundamental role in maintaining tissue homeostasis. Activated macrophages show altered immunometabolism and metabolic changes governing immune effector… read more here.
Keywords: stimulated macrophages; secretion; role metabolic; activated macrophages ... See more keywords
Immune-Mediated Inflammatory Responses of Alveolar Epithelial Cells: Implications for COVID-19 Lung Pathology
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030618
Abstract: Background. Clinical and experimental evidence point to a dysregulated immune response caused by SARS-CoV-2 as the primary mechanism of lung disease in COVID-19. However, the pathogenic mechanisms underlying COVID-19-associated ARDS (Acute Respiratory Distress Syndrome) remain… read more here.
Keywords: inflammatory responses; activated macrophages; lung; pathology ... See more keywords