C-4 Regioselective Alkylation of Pyridines Driven by Mechanochemically Activated Magnesium Metal.
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DOI: 10.1021/acs.orglett.3c00684
Abstract: Mechanochemically activated magnesium(0) metal as a highly active mediator driving direct C-4-H alkylation of pyridines with alkyl halides has been developed. Excellent regioselectivity and substrate scope, including those containing reducible functionalities, free amines, and alcohols,… read more here.
Keywords: activated magnesium; magnesium metal; alkylation pyridines; mechanochemically activated ... See more keywords