HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases
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DOI: 10.1002/glia.23137
Abstract: In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), chronic activation of microglia contributes to disease progression. Activated microglia produce cytokines, chemokines, and other factors that normally serve to clear infection or damaged tissue either… read more here.
Keywords: phenotype; hur; neurodegenerative diseases; amyotrophic lateral ... See more keywords
Iron‐sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia
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DOI: 10.1002/glia.23178
Abstract: Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite‐mediated damage of myelin. Here, we… read more here.
Keywords: iron sulfur; glutaredoxin; activated microglia; damage ... See more keywords
Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24218
Abstract: Retinal neovascularization (NV) is the major cause of severe visual impairment in patients with ischemic eye diseases. While it is known that retinal microglia contribute to both physiological and pathological angiogenesis, the molecular mechanisms by… read more here.
Keywords: activated microglia; igf1 expression; retinal neovascularization; tgf ... See more keywords
Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02144-5
Abstract: Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. The role of the pore-forming protein gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome… read more here.
Keywords: depression; casp; paeoniflorin; pyroptosis ... See more keywords
Internalization of Particulate Delivery Systems by Activated Microglia Influenced the Therapeutic Efficacy of Simvastatin Repurposing for Neuroinflammation.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118690
Abstract: We recently evaluated the suitability of polymersome delivery systems in simvastatin repurposing for treating neuroinflammation. The goal of the current study is to elucidate the therapeutic impact of particulate internalization by activated microglia on the… read more here.
Keywords: internalization; simvastatin; delivery; delivery systems ... See more keywords
Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.04.001
Abstract: Tenuigenin (TEN), an active component of Polygala tenuifolia root extracts, has been shown to provide neuroprotection in neurodegenerative disorders. To date, most of these studies have focused on the effect that TEN has on neurons.… read more here.
Keywords: matrix metalloproteinase; activated microglia; release nitric; nitric oxide ... See more keywords
Distribution and polarization of microglia and macrophages at injured sites and the lumbar enlargement after spinal cord injury
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135152
Abstract: Spinal cord injury (SCI) causes loss of locomotor function and chronic neuropathic pain (NeP). Hematogenous macrophages and activated microglia are key monocytic lineage cell types in the response to SCI, and each has M1- and… read more here.
Keywords: lumbar enlargement; sci; injured site; activated microglia ... See more keywords
Activated Microglia Targeting Dendrimer-Minocycline Conjugate as Therapeutics for Neuroinflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00569
Abstract: Brain-related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity and mortality. The lack of effective therapies and the relatively dry central nervous system (CNS) drug pipeline pose formidable challenge.… read more here.
Keywords: minocycline; minocycline conjugate; conjugate; drug ... See more keywords
In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0784-7
Abstract: Alterations in the cortical dopamine system and microglial activation have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), one of neurodevelopmental disorders that can be conventionally treated with a dopamine enhancer (methylphenidate) albeit unsatisfactorily.… read more here.
Keywords: hyperactivity; hyperactivity disorder; dopamine receptor; activated microglia ... See more keywords
Açaí (Euterpe oleracea Mart.) presents anti-neuroinflammatory capacity in LPS-activated microglia cells.
Sign Up to like & getrecommendations! Published in 2020 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2020.1842044
Abstract: INTRODUCTION Neuropsychiatric diseases are responsible for one of the highest burden of morbidity and mortality worldwide. These illnesses include schizophrenia, bipolar disorder, and major depression. Individuals affected by these diseases may present mitochondrial dysfunction and… read more here.
Keywords: anti neuroinflammatory; microglia cells; lps activated; cell cycle ... See more keywords
Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection.
Sign Up to like & getrecommendations! Published in 2017 at "Viral immunology"
DOI: 10.1089/vim.2016.0175
Abstract: The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other… read more here.
Keywords: complement; macrophages activated; activated microglia; components expressed ... See more keywords