Monocytes complexed to platelets differentiate into functionally deficient dendritic cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0620-460rr
Abstract: In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2‐microglobulin, and IL‐1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes,… read more here.
Keywords: activated platelets; dcs; dendritic cells; complexed platelets ... See more keywords
Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2016.12.007
Abstract: Monocytes and macrophage combat infections and maintain homeostatic balance by engulfing microbes and apoptotic cells, and releasing inflammatory cytokines. Studies have described that these cells develop anti-inflammatory properties upon recycling the free-hemoglobin (Hb) in hemolytic… read more here.
Keywords: phenotype; hemolytic disorders; activated platelets; phenotype monocytes ... See more keywords
Platelet Activation via Glycoprotein VI Initiates Thrombin Generation: A Potential Role for Platelet-Derived Factor IX?
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0042-1744379
Abstract: Collagen triggers coagulation via activation of factor (F) XII. In a platelet-rich environment, collagen can also trigger coagulation independently of FXII. We studied a novel mechanism of coagulation initiation via collagen-dependent platelet activation using thrombin… read more here.
Keywords: activated platelets; platelet activation; factor; platelet ... See more keywords
Distribution and quantification of activated platelets in platelet-rich fibrin matrices.
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1856359
Abstract: Platelet-rich fibrin (PRF) has been widely applied in regenerative therapy owing to its simple preparation protocol. To date, the original protocol for preparing leukocyte-rich (L)-PRF has been modified to produce derivatives such as advanced (A)-PRF,… read more here.
Keywords: platelet rich; fibrin matrices; activated platelets; rich fibrin ... See more keywords
A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2018 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx218
Abstract: Aims CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its bleeding side effect. With the goal of harnessing its therapeutic potential while avoiding haemostatic problems,… read more here.
Keywords: targ cd39; activated platelets; fusion protein; single chain ... See more keywords
4323Detection of early inflammation in myocarditis by molecular magnetic resonance imaging of activated platelets
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0160
Abstract: A noninvasive imaging strategy for diagnosis and localization of early myocarditis would be of great clinical interest. However, resolution of current imaging techniques is limited. Platelets play an important role in inflammatory processes but the… read more here.
Keywords: control; activated platelets; imaging; libs mpio ... See more keywords
Activated Platelets Mediate Monocyte Killing of Klebsiella pneumoniae
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00556-22
Abstract: Platelets are known for essential activities in hemostasis and for their important contribution to protection against infectious pathogens. Klebsiella pneumoniae is an opportunistic pathogen widely known to cause nosocomial infections. Recently, hypervirulent strains of K.… read more here.
Keywords: monocyte; platelets mediate; activated platelets; pneumoniae ... See more keywords
Phenotypic characterization of acoustically enriched extracellular vesicles from pathogen-activated platelets.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of innate immunity"
DOI: 10.1159/000531266
Abstract: Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune… read more here.
Keywords: extracellular vesicles; activated platelets; pathogen activated; acoustically enriched ... See more keywords
Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-09-0722
Abstract: Using intravital confocal microscopy, we observed previously that the process of platelet phosphatidylserine (PS) exposure, fibrin formation and lysine binding site-dependent plasminogen (plg) accumulation took place only in the centre of thrombi, not at their… read more here.
Keywords: coagulation; inhibitor; initiation; microscopy ... See more keywords
Activated Platelets Convert CD14+CD16- Into CD14+CD16+ Monocytes With Enhanced FcγR-Mediated Phagocytosis and Skewed M2 Polarization
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.611133
Abstract: Monocytes are important cellular effectors of innate immune defense. Human monocytes are heterogeneous and can be classified into three distinct subsets based on CD14 and CD16 expression. The expansion of intermediate CD14+CD16+ monocytes has been… read more here.
Keywords: phagocytosis; cd16; activated platelets; cd16 monocytes ... See more keywords
Thrombin-Activated Platelets Protect Vascular Endothelium against Tumor Cell Extravasation by Targeting Endothelial VCAM-1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073433
Abstract: When activated by thrombin, the platelets release their granular store of factors. These thrombin-activated platelets (TAPLT) have been shown to be capable of ameliorating pro-inflammatory processes. In this study, we tested if TAPLT could also… read more here.
Keywords: cell; activated platelets; extravasation; thrombin activated ... See more keywords