Phylogenetic and developmental analyses indicate complex functions of calcium‐activated potassium channels in zebrafish embryonic development
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.329
Abstract: Calcium‐activated potassium channels (KCa) are a specific type of potassium channel activated by intracellular calcium concentration changes. This group of potassium channels plays fundamental roles ranging from regulating neuronal excitability to immune cell activation. Many… read more here.
Keywords: potassium channels; activated potassium; potassium; calcium activated ... See more keywords
Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-021-06045-w
Abstract: Rationale The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders. Objective We ascertained whether the SK channel is impaired in the… read more here.
Keywords: channel; activated potassium; conductance calcium; activity ... See more keywords
Functional Regulation of Small Conductance Calcium Activated Potassium Channel on Atrial Myocytes by Hydrogen Sulfide in Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2274
Abstract: Previous studies established an essential role for Small Conductance Calcium Activated Potassium(SK) channels in cardiac dysrhythmias, especial in atrial dysrhythmias. Hydrogen sulfide (H2S), an endogenously generated gaseous transmitter, has recently been suggested to regulate cardiovascular… read more here.
Keywords: activated potassium; small conductance; channel; conductance calcium ... See more keywords
Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2425494122
Abstract: Significance An approach to turn old drugs into new drugs is “selective optimization of a side activity (SOSA).” Here, we modified the 1,4-dihydropyridine nucleus and transformed its side activity (weak blockade of the calcium-activated potassium… read more here.
Keywords: calcium activated; activated potassium; potassium channel; kca ... See more keywords
Cardioprotective actions of the sodium-activated potassium channel Slack (aka Slo2.2, KNa1.1 or KCNT1)
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DOI: 10.1093/ehjci/ehaa946.3646
Abstract: Sodium-activated potassium channels (KNa) Slack (sequence like a calcium-activated potassium channel, aka Slo 2.2, KNa1.1 or KCNT1) are widely expressed throughout neuronal tissue, whereas their presence and function in the cardiovascular system is not well… read more here.
Keywords: activated potassium; slack gko; sodium activated; slack ... See more keywords
Calcium-activated Potassium Channels as Amplifiers of TRPV4-mediated Pulmonary Edema Formation in Male Mice
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DOI: 10.1097/aln.0000000000005171
Abstract: Background As a mechanosensitive cation channel and key regulator of vascular barrier function, endothelial transient receptor potential vanilloid type 4 (TRPV4) contributes critically to ventilator-induced lung injury and edema formation. Ca2+ influx via TRPV4 can… read more here.
Keywords: induced lung; activated potassium; lung injury; calcium ... See more keywords
Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis
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DOI: 10.1177/00368504211043763
Abstract: Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated. Our present study aimed to explore the role of small conductance… read more here.
Keywords: activated potassium; small conductance; channel; ca2 activated ... See more keywords
From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics
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DOI: 10.15420/ecr.2024.41
Abstract: Despite significant advances in its management, AF remains a major healthcare burden affecting millions of individuals. Rhythm control with antiarrhythmic drugs or catheter ablation has been shown to improve symptoms and outcomes in AF patients,… read more here.
Keywords: conductance calcium; calcium activated; activated potassium; small conductance ... See more keywords
In silico prediction of the impact of genomic variations in the small conductance calcium activated potassium channel SK3 structure and function
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DOI: 10.3389/fnins.2025.1631536
Abstract: The small-conductance calcium-activated potassium channel SK3, encoded by the KCNN3 gene, plays a critical role in regulating dopaminergic neuron (DN) firing patterns by modulating after hyperpolarization currents. SK3 dysfunction has been implicated in neuropsychiatric and… read more here.
Keywords: calcium activated; sk3; activated potassium; conductance calcium ... See more keywords
Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function
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DOI: 10.3389/fphar.2017.00660
Abstract: Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1) conductance, NS309… read more here.
Keywords: activated potassium; endothelial erectile; erectile function; ns309 ns4591 ... See more keywords
Improved Dewaterability of Waste Activated Sludge by Fe(II)-Activated Potassium Periodate Oxidation
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DOI: 10.3390/ijerph192214726
Abstract: Fe(II)-activated potassium periodate (KIO4) oxidation was used to improve the dewaterability of waste-activated sludge for the first time. Compared with those of raw sludge, the capillary suction time (CST), specific resistance filtration (SRF), and water… read more here.
Keywords: oxidation; activated potassium; sludge; dewaterability waste ... See more keywords