Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9949
Abstract: Healthy guts exclude oxygen Normally, the lumen of the colon lacks oxygen. Fastidiously anaerobic butyrate-producing bacteria thrive in the colon; by ablating these organisms, antibiotic treatment removes butyrate. Byndloss et al. discovered that loss of… read more here.
Keywords: ppar signaling; expansion; butyrate; microbiota activated ... See more keywords
Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.881462
Abstract: Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid… read more here.
Keywords: activated ppar; superinfection; ppar inhibits; eicosanoid activated ... See more keywords