Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)
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DOI: 10.1002/iub.2619
Abstract: The hypoxic tumour microenvironment (hTME), arising from inadequate and chaotic vascularity, can present a major obstacle for the treatment of solid tumours. Hypoxic tumour cells compromise responses to treatment since they can generate resistance to… read more here.
Keywords: tumour microenvironment; unidirectional hypoxia; top2a; activated prodrugs ... See more keywords
Glycosidase activated prodrugs for targeted cancer therapy.
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DOI: 10.1039/d2cs00379a
Abstract: In this review glycosidase activated prodrugs that target cancer cells are discussed. Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release the anticancer drug at the desired site of action, hence minimising the toxic… read more here.
Keywords: targeted cancer; prodrugs targeted; activated prodrugs; glycosidase activated ... See more keywords
Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer Therapy
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DOI: 10.1158/1078-0432.ccr-16-0895
Abstract: Hypoxia is a known feature of aggressive solid tumors as well as a critical hallmark of the niche in aggressive hematologic malignances. Hypoxia is associated with insufficient response to standard therapy, resulting in disease progression… read more here.
Keywords: cancer; activated prodrugs; cancer therapy; hypoxia activated ... See more keywords
Abstract 4513: Investigation of bystander effects of hypoxia activated prodrugs using three dimensional cell cultures
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DOI: 10.1158/1538-7445.am2017-4513
Abstract: Background: Hypoxia in solid tumors acts as the major barrier to anti-cancer therapies and promotes tumor progression. Hypoxia-activated prodrugs (HAPs) are designed to not only eliminate these resistant cells, but also to exploit hypoxia as… read more here.
Keywords: hypoxia activated; activated prodrugs; effect; bystander ... See more keywords
Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors
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DOI: 10.3390/molecules24081559
Abstract: Poly(ADP-ribose)polymerase (PARP) inhibitors (PARPi) have recently been approved for the treatment of breast and ovarian tumors with defects in homologous recombination repair (HRR). Although it has been demonstrated that PARPi also sensitize HRR competent tumors… read more here.
Keywords: parp inhibitors; hypoxia activated; activated prodrugs; parpi ... See more keywords