Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
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DOI: 10.1158/2326-6066.cir-21-0831
Abstract: WTX 124 is an inducible IL-2 prodrug that is selectively activated in the tumor microenvironment. Administration of WTX-124 generates potent antitumor immunity by activating tumor-infiltrating lymphocytes while preventing the toxicity associated with systemic, high dose… read more here.
Keywords: activated promotes; promotes antitumor; discovery conditionally; immunity ... See more keywords