Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.4213
Abstract: Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors The Oxford Eye Hospital and the Oxford Experimental Cancer Centre collaborate in monitoring patients in a number of early-phase clinical trials. In this study, we report the ocular… read more here.
Keywords: kinase inhibitors; protein kinase; mitogen activated; activated protein ... See more keywords
Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700693
Abstract: The effect of LDH samples comprised of chloride anions intercalated between positive layers of magnesium/aluminum (Mg-Al LDH) or zinc/aluminum (Zn-Al LDH) chemical composition on pre-osteoblast performance is investigated. Non-cytotoxic concentrations of both LDHs modulated pre-osteoblast… read more here.
Keywords: layered double; marker genes; activated protein; differentiation ... See more keywords
AMP‐activated protein kinase is a key regulator of obesity‐associated factors
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3767
Abstract: An imbalance between caloric intake and energy expenditure leads to obesity. Obesity is an important risk factor for the development of several metabolic diseases including insulin resistance, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular… read more here.
Keywords: protein kinase; amp activated; activated protein; associated factors ... See more keywords
Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10758
Abstract: Our previous works indicated that geniposide could regulate glucose‐stimulated insulin secretion (GSIS), and improved chronic high glucose‐induced dysfunctions in pancreatic β cells, but the molecular mechanisms remain largely unknown. In the present study, we investigated… read more here.
Keywords: activated protein; high glucose; pancreatic cells; injury ... See more keywords
An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
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DOI: 10.1002/cmdc.201900303
Abstract: The mitogen‐activated protein kinase p38α pathway has been an attractive target for the treatment of inflammatory conditions such as rheumatoid arthritis. While a number of p38α inhibitors have been taken to the clinic, they have… read more here.
Keywords: prevention activation; activated protein; mk2; p38 ... See more keywords
Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate‐activated protein kinase—UNC‐51‐like kinase 1 pathway
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1731
Abstract: Positive regulation of autophagy by Euryale ferox Salisb (ES) leads to antidepressant effects. This study focused on the potential antidepressant mechanisms induced by the petroleum ether fraction of ES (ES‐PE) in the chronically unpredictable mild… read more here.
Keywords: kinase; activated protein; protein kinase; euryale ferox ... See more keywords
Perilaldehyde activates AMP‐activated protein kinase to suppress the growth of gastric cancer via induction of autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27491
Abstract: Background and Aim: Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, is very critical to health maintenance, for a wide range of human chronic diseases, including cancers. AMP‐activated protein kinase (AMPK) has… read more here.
Keywords: gastric cancer; activated protein; autophagy; protein kinase ... See more keywords
Regulation of immune cell signaling by activated protein C
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mir0817-338r
Abstract: Innate immune cells are an essential part of the host defense response, promoting inflammation through release of proinflammatory cytokines or formation of neutrophil extracellular traps. While these processes are important for defense against infectious agents… read more here.
Keywords: immune; neutrophil extracellular; activated protein; regulation immune ... See more keywords
Dietary apple polyphenols promote fat browning in high-fat diet-induced obese mice through activation of AMP-activated protein kinase (AMPK) α.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10248
Abstract: BACKGROUND Promoting brown and beige adipogenesis contributes to adaptive thermogenesis, which provides a defense against obesity and related disorders. Apple polyphenols (APs) play a significant role in treating variety of metabolic diseases. The present study… read more here.
Keywords: obese mice; apple polyphenols; activated protein; protein kinase ... See more keywords
Mapping p38α mitogen‐activated protein kinase signaling by proximity‐dependent labeling
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DOI: 10.1002/pro.3854
Abstract: Mitogen‐activated protein (MAP) kinase signaling is central to multiple cellular responses and processes. MAP kinase p38α is the best characterized member of the p38 MAP kinase family. Upstream factors and downstream targets of p38α have… read more here.
Keywords: kinase; activated protein; p38; map kinase ... See more keywords
Static magnetic fields enhance dental pulp stem cell proliferation by activating the p38 mitogen‐activated protein kinase pathway as its putative mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2333
Abstract: Dental pulp stem cells (DPSCs) can be a potential stem cell resource for clinical cell therapy and tissue engineering. However, obtaining a sufficient number of DPSCs for repairing defects is still an issue in clinical… read more here.
Keywords: activated protein; p38 mitogen; proliferation; cell ... See more keywords