Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2256
Abstract: Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment… read more here.
Keywords: peroxisome proliferator; preterm babies; proliferator activated; activated receptor ... See more keywords
In vitro and in silico analyses of Vicia faba L. on Peroxisome proliferator–activated receptor gamma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27123
Abstract: The agonists of peroxisome proliferator–activated receptor gamma (PPARγ) from natural victual products were used as antidiabetic agents. Faba bean (Vicia faba L.) is a consequential legume that was known to possess potential antidiabetic activity, whose… read more here.
Keywords: peroxisome proliferator; faba bean; proliferator activated; activated receptor ... See more keywords
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and disease.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21970
Abstract: The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles and unhealthy dietary patterns. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor regulating multiple biological processes, such as lipid metabolism and… read more here.
Keywords: inflammation; peroxisome proliferator; ppar; proliferator activated ... See more keywords
Role of Peroxisome Proliferator‐Activated Receptor (PPARγ) in Metabolic Disorders in SGA with Catch‐Up Growth
Sign Up to like & getrecommendations! Published in 2018 at "Obesity"
DOI: 10.1002/oby.22030
Abstract: Abnormal fat metabolism is a major disorder in adults who were small for gestational age (SGA). Peroxisome prolferator‐activated receptor (PPARγ) participates in adipocyte differentiation and the regulation of lipid metabolism. This study explored the role… read more here.
Keywords: ppar; receptor ppar; catch growth; activated receptor ... See more keywords
Integrated in silico–in vitro screening of ovarian cancer peroxisome proliferator-activated receptor-γ agonists against a biogenic compound library
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2060-1
Abstract: In recent years, peroxisome proliferator-activated receptor-γ (PPARγ) activation by selective agonists has been emerged as a new and promising strategy for ovarian cancer therapy and prevention. Here, an integrated screening protocol that combined computational protein–ligand… read more here.
Keywords: peroxisome proliferator; activated receptor; proliferator activated; ovarian cancer ... See more keywords
Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0554-5
Abstract: Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is expressed in diverse cell types, including vessels, immune and glial cells, and neurons.… read more here.
Keywords: peroxisome proliferator; proliferator activated; activated receptor; receptor gamma ... See more keywords
Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0730-y
Abstract: PurposeThe peroxisome proliferator-activated receptor γ (PPARγ) is highly expressed in adipose tissue and functions as transcriptional regulator of metabolism and adipocyte differentiation. Angiopoietin-like protein 4 (ANGPTL4), a central player in various aspects of energy homoeostasis,… read more here.
Keywords: peroxisome proliferator; obese children; proliferator activated; activated receptor ... See more keywords
Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.05.040
Abstract: The Bcl-2 homolog Bcl-xL is emerging as a key factor in tumorigenesis due to its prominent pro-survival and cell death-independent functions. However, the regulation of Bcl-xL by microenvironment and its implication in cancer therapy of… read more here.
Keywords: par2; egfr targeted; protease activated; activated receptor ... See more keywords
Protease activated receptor 2 signaling promotes self-renewal and metastasis in colorectal cancer through β-catenin and periostin.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.08.032
Abstract: The maintenance and expansion of cancer stem-like cells (CSCs) is necessary for metastasis. Although protease-activated receptor 2 (PAR2) is strongly associated with colorectal cancer (CRC) progression, it is unclear how it regulates distal metastasis, and… read more here.
Keywords: par2; catenin; protease activated; activated receptor ... See more keywords
Bisphenol a: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.03.012
Abstract: There is significant evidence of globally ubiquitous prenatal exposures to bisphenol A (BPA). Childhood obesity as an epidemic has been a global concern for over a decade. Experimental models and epidemiological evidence suggest that BPA… read more here.
Keywords: proliferator activated; childhood obesity; activated receptor; review ... See more keywords
Neurovascular protection by peroxisome proliferator-activated receptor α in ischemic stroke
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DOI: 10.1016/j.expneurol.2020.113323
Abstract: Ischemic stroke is a leading cause of death and disability worldwide. Currently, the only pharmacological therapy for ischemic stroke is thrombolysis with tissue plasminogen activator that has a narrow therapeutic window and increases the risk… read more here.
Keywords: peroxisome proliferator; ischemic stroke; proliferator activated; activated receptor ... See more keywords