Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300043
Abstract: Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of LDs in cells is closely related to the development… read more here.
Keywords: peroxisome proliferator; proliferator activated; lipid droplets; mouse liver ... See more keywords
Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Actions on Metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-11488-6_3
Abstract: Peroxisome proliferator-activated receptors (PPARs) are multi-domains proteins, belonging to the superfamily of nuclear receptors, which mainly act as ligand-activated transcription factors. A variety of lipophilic molecules, including long-chain polyunsaturated fatty acids and eicosanoids, are capable… read more here.
Keywords: peroxisome proliferator; metabolism; proliferator activated; activated receptors ... See more keywords
Structure-based design, synthesis, PPAR-γ activation, and molecular docking of N-substituted phthalimides
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1867-0
Abstract: N-substituted phthalimides showed peroxisome proliferator-activated receptors-γ activation in rat liver epithelial Ac2F cells in our previous study. In order to explore better peroxisome proliferator-activated receptors-γ agonists, new N-substituted phthalimide derivatives were designed and synthesized based… read more here.
Keywords: peroxisome proliferator; substituted phthalimides; proliferator activated; activated receptors ... See more keywords
Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.08.043
Abstract: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to be a promising therapeutic target for several neurodegenerative disorders, which includes Parkinson disease, Alzheimer's disease, Huntington disease and Amyotrophic Lateral Sclerosis. PPARs play an… read more here.
Keywords: peroxisome proliferator; proliferator activated; neurodegenerative disorders; activated receptors ... See more keywords
The role of peroxisome proliferator-activated receptors in healthy and diseased eyes.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108617
Abstract: Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism. Three subtypes of PPARs are known: PPAR-alpha (PPARα), PPAR-gamma (PPARγ), and PPAR-beta/delta (PPARβ/δ). PPARα… read more here.
Keywords: ppar; peroxisome proliferator; ppar ppar; proliferator activated ... See more keywords
Phthalate Monoesters Act Through Peroxisome Proliferator-Activated Receptors in the Mouse Ovary.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2022.04.002
Abstract: Widespread use of phthalates as solvents and plasticizers leads to everyday human exposure. The mechanisms by which phthalate metabolites act as ovarian toxicants are not fully understood. Thus, this study tested the hypothesis that the… read more here.
Keywords: peroxisome proliferator; act peroxisome; phthalate metabolites; phthalate ... See more keywords
The domino effect triggered by the tethered ligand of the protease activated receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.08.004
Abstract: Protease activated receptors (PARs) are G-protein coupled receptors (GPCRs) that have a unique activation mechanism. Unlike other GPCRs that can be activated by free ligands, under physiological conditions, PARs are activated by the tethered ligand,… read more here.
Keywords: tethered ligand; domino effect; protease activated; activated receptors ... See more keywords
Estimation of Per- and Polyfluorinated Alkyl Substance Induction Equivalency Factors for Humpback Dolphins by Transactivation Potencies of Peroxisome Proliferator-Activated Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c05044
Abstract: The potential risks of per- and polyfluoroalkyl substance (PFAS) accumulation in nearshore dolphins are not well understood. Here, transcriptional activities of 12 PFAS on peroxisome proliferator-activated receptors (PPAR-α, -β/δ, and -γ) in Indo-Pacific humpback dolphins… read more here.
Keywords: humpback dolphins; peroxisome proliferator; proliferator activated; induction equivalency ... See more keywords
The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/5193572
Abstract: Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial… read more here.
Keywords: tissue metabolism; periodontal tissue; proteinase; activated receptors ... See more keywords
Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s335502
Abstract: Abstract The pathogenesis and course of inflammatory bowel diseases are related to both immune system disorders and dysfunction of colon permeability. Moreover, co-existing diseases in patients with Crohn’s disease and ulcerative colitis are identified. Currently,… read more here.
Keywords: bowel diseases; protease activated; activated receptors; inflammatory bowel ... See more keywords
Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.709902
Abstract: Embryo implantation is a complex and tightly regulated process. In humans, uterine luminal epithelium functions as a biosensor gauging the embryo quality and transmitting this information to the underlying endometrial stromal cells. This quality control… read more here.
Keywords: mediate trypsin; trypsin; activated receptors; human uterine ... See more keywords