Insulin-like growth factor-I activates NFκB and NLRP3 inflammatory signalling via ROS in cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101583
Abstract: Previous studies have demonstrated that insulin-like growth factor-I (IGF-1) and reactive oxygen species (ROS) are involved in the development and progression of various cancers. However, their regulatory mechanism remains unknown. In this study, we treated… read more here.
Keywords: activates nlrp3; inflammatory signalling; insulin like; cancer cells ... See more keywords
Soluble Uric Acid Activates the NLRP3 Inflammasome
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DOI: 10.1038/srep39884
Abstract: Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in… read more here.
Keywords: nlrp3 inflammasome; uric acid; activates nlrp3; soluble uric ... See more keywords
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13623
Abstract: Neuroinflammation is considered one of major factors in the pathogenesis of Alzheimer's disease (AD). In particular, inflammasome activation, including NLRP3 inflammasome in microglia, is regarded as fundamental for the pro‐inflammatory response of immune cells. However,… read more here.
Keywords: syk ampk; amyloid activates; activates nlrp3; nlrp3 inflammasomes ... See more keywords