Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease
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DOI: 10.1007/s40263-018-0497-5
Abstract: Parkinson’s disease is a progressive neurodegenerative disease characterized by Lewy body pathology of which the primary constituent is aggregated misfolded alpha-synuclein protein. Currently, there are no clinical therapies for treatment of the underlying alpha-synuclein dysfunction… read more here.
Keywords: therapeutic strategy; disease; parkinson disease; alpha synuclein ... See more keywords
The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152906
Abstract: Fluoride is one of the most widely distributed elements in nature, while some fluorine-containing compounds are toxic to several vertebrates at certain levels. The current study was performed to evaluate the nephrotoxic effects of fluoride… read more here.
Keywords: autophagy apoptosis; glucolipid metabolism; fluoride exposure; exposure ... See more keywords
Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4273789
Abstract: Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma applanatum. Their structures were established through extensive spectroscopic analyses, quantum chemical calculations, including calculated… read more here.
Keywords: inhibit tau; activating autophagy; pentacyclic skeleton; fused pentacyclic ... See more keywords
URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells
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DOI: 10.7150/ijbs.55689
Abstract: Radiotherapy has been extensively applied in cancer treatment. However, this treatment is ineffective in Hepatocellular carcinoma (HCC) due to lack of radiosensitivity. Unconventional prefoldin RPB5 interactor 1 (URI1) exhibits characteristics similar to those oncoproteins, which… read more here.
Keywords: hepatocellular carcinoma; irradiation; ros activating; irradiation induced ... See more keywords
USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP
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DOI: 10.7150/jca.52158
Abstract: Chemotherapy plays an important role in the treatment of patients with colorectal cancer (CRC). However, the resistance to chemotherapy severely affects the prognosis of CRC patients and the mechanisms are still poorly understood. Our study… read more here.
Keywords: induce resistance; colorectal cancer; resistance fluorouracil; resistance ... See more keywords