Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy
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DOI: 10.1021/acs.orglett.2c04149
Abstract: A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5–C-8 positions… read more here.
Keywords: activating group; group free; alkylation; metal activating ... See more keywords