Molecular-scale spatio-chemical control of the activating-inhibitory signal integration in NK cells
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DOI: 10.1126/sciadv.abc1640
Abstract: Molecular devices for the spatial control of activating and inhibitory receptors help in their signal integration. The role of juxtaposition of activating and inhibitory receptors in signal inhibition of cytotoxic lymphocytes remains strongly debated. The… read more here.
Keywords: molecular scale; activating inhibitory; signal integration; control activating ... See more keywords
Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion
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DOI: 10.1172/jci.insight.150079
Abstract: NK cell exhaustion is caused by chronic exposure to activating stimuli during viral infection, tumorigenesis, and prolonged cytokine treatment. Evidence suggests that exhaustion may play a role in disease progression. However, relative to T cell… read more here.
Keywords: cell; balanced engagement; exhaustion; engagement activating ... See more keywords