ACTIVATING NOTCH1 MUTATION IN HIGH-GRADE EVOLUTION OF ADENOID CYSTIC CARCINOMA
Sign Up to like & getrecommendations! Published in 2019 at "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"
DOI: 10.1016/j.oooo.2019.02.171
Abstract: Objective Salivary adenoid cystic carcinoma(SACC) is identified as a tumor with biphasic differentiation of epithelial and myoepithelial cells, showing tubular, cribriform and solid subtypes. The solid subtype is considered as high-grade with more aggressiveness and… read more here.
Keywords: high grade; activating notch1; grade; cystic carcinoma ... See more keywords
Association of activating NOTCH1 mutations in adenoid cystic carcinoma with shorter progression-free survival to systemic therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.6089
Abstract: 6089Background: We previously reported that activating NOTCH1 mutations occurs in approximately 20% of ACCs and drive a phenotype with solid histology, liver and bone metastases, poor prognosis, an... read more here.
Keywords: mutations adenoid; notch1 mutations; cystic carcinoma; association activating ... See more keywords