A prenylated flavonoid, 10‐oxomornigrol F, exhibits anti‐inflammatory effects by activating the Nrf2/heme oxygenase‐1 pathway in macrophage cells
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.12.015
Abstract: ABSTRACT Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti‐inflammatory effect in murine macrophages of a prenylated flavonoid, 10‐oxomornigrol F (OMF),… read more here.
Keywords: anti inflammatory; prenylated flavonoid; activating nrf2; pathway ... See more keywords
Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117901
Abstract: AIMS Cyclophosphamide (CTX) is an effective anti-tumor and immunosuppressive agent, but it induces nephrotoxicity in clinical applications. The present study aimed to evaluate the protective effect of pyrroloquinoline quinone (PQQ) on CTX-induced nephrotoxicity. MAIN METHODS… read more here.
Keywords: pyrroloquinoline quinone; induced nephrotoxicity; effect pyrroloquinoline; activating nrf2 ... See more keywords
Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2088384
Abstract: Abstract Objective Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism… read more here.
Keywords: rat chondrocytes; activating nrf2; signaling pathway; nrf2 signaling ... See more keywords
Rumex nervosus could alleviate streptozotocin-induced diabetic nephropathy in rats by activating Nrf2 signaling
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DOI: 10.1177/00368504221102751
Abstract: This study tested the protective effect of Rumex nervous (R. nervosus) methanol extract against streptozotocin (STZ)-mediated type 1 diabetes mellitus (T1DM)-induced nephropathy in rats and examined if this protection involves activating the nuclear factor erythroid… read more here.
Keywords: factor; activating nrf2; rumex nervosus; nephropathy rats ... See more keywords
Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway
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DOI: 10.18632/oncotarget.20546
Abstract: In the studies of chemoprevention, the Nrf2-ARE signaling pathway has received widespread attention due to its anti-inflammatory and anti-oxidation effects. Our previous study indicated that atractylenolide II, which is an active component of Atractylodes macrocephala… read more here.
Keywords: via activating; nrf2 pathway; nrf2 signaling; mammary tumorigenesis ... See more keywords
Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.889226
Abstract: Intracerebral hemorrhage (ICH), a severe hemorrhagic stroke, induces cerebral oxidative stress and severe secondary neurological injury. Curcumin was demonstrated to inhibit oxidative stress in the brain after ICH. However, the pharmacological mechanism needs further research.… read more here.
Keywords: stress; rat; oxidative stress; curcumin ... See more keywords
Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways
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DOI: 10.3390/antiox10020158
Abstract: T-2 toxin, which is mainly produced by specific strains of Fusarium in nature, can induce immunotoxicity and oxidative stress, resulting in immune organ dysfunction and apoptosis. Betulinic acid (BA), a pentacyclic triterpenoids from nature plants,… read more here.
Keywords: spleen oxidative; oxidative damage; betulinic acid; activating nrf2 ... See more keywords
4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.74456
Abstract: Introduction: Sepsis is a major global health challenge with high mortality rates and no effective treatment. Recent studies have suggested that sepsis may be associated with immune system dysfunction. Itaconate may exert anti-inflammatory effects via… read more here.
Keywords: sepsis; mouse model; anti inflammatory; activating nrf2 ... See more keywords