Cyanidin-3-rutinoside increases glucose uptake by activating the PI3K/Akt pathway in 3T3-L1 adipocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.06.007
Abstract: In this study, the effect of cyanidin-3-rutinoside (C3R) on glucose uptake by 3T3-L1 adipocytes was studied. C3R significantly increased glucose uptake, which was associated with enhanced plasma membrane glucose transporter type 4 (PM-GLUT4) expression in… read more here.
Keywords: 3t3 adipocytes; glucose uptake; cyanidin rutinoside; pi3k akt ... See more keywords
Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.110653
Abstract: This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague-Dawley (SD) rats were unilaterally injected with 6-OHDA (8 μg/4 μL)… read more here.
Keywords: akt signaling; induced apoptosis; pi3k akt; signaling pathway ... See more keywords
Abstract CT024: Results of a phase I dose escalation study of ARQ 751 in adult subjects with advanced solid tumors with AKT1, 2, 3 genetic alterations, activating PI3K mutations, PTEN-null, or other known actionable PTEN mutations
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DOI: 10.1158/1538-7445.am2018-ct024
Abstract: Background: Dysregulation of the PI3K-AKT signaling pathway is associated with a number of cancers. and plays a critical role in cancer initiation and progression. AKT can be activated through activated receptor tyrosine kinases, gain-of-function mutations… read more here.
Keywords: advanced solid; solid tumors; dose escalation; arq 751 ... See more keywords
Alantolactone reduced neuron injury via activating PI3K/Akt signaling pathway after subarachnoid hemorrhage in rats
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DOI: 10.1371/journal.pone.0270410
Abstract: Subarachnoid hemorrhage (SAH) is a common disease with high morbidity and mortality, which can cause pathological, physiological, and biological reactions. SAH causes a series of responses such as neuronal and cerebral cortex damage, which in… read more here.
Keywords: pi3k akt; signaling pathway; subarachnoid hemorrhage; akt signaling ... See more keywords
Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling
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DOI: 10.3390/cancers14133039
Abstract: Simple Summary Chondrosarcoma and inflammatory arthritis are two joint-damaging diseases. Here, we examined whether a counterintuitive approach of activating tumorigenic and inflammatory signaling may generate joint-protective proteomes in mesenchymal stem cells and chondrocytes for the… read more here.
Keywords: gapdh; tnf; inflammatory; chondroprotective proteomes ... See more keywords