In silico identification of natural product inhibitors for γ‐secretase activating protein, a therapeutic target for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28316
Abstract: Alzheimer's disease (AD) is clinically characterized by the aggregation of neurotoxic amyloid‐β (Aβ) peptides in the brain. γ‐Secretase catalyzes the reaction of Aβ formation. Inhibition of γ‐secretase activating protein (GSAP) reduces Aβ production without disrupting… read more here.
Keywords: secretase activating; gsap; alzheimer disease; activating protein ... See more keywords
Solution structure and dynamics of the mitochondrial‐targeted GTPase‐activating protein (GAP) VopE by an integrated NMR/SAXS approach
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4282
Abstract: The bacterial pathogen Vibrio cholerae use a type III secretion system to inject effector proteins into a host cell. Recently, a putative Toxic GTPase Activating Protein (ToxGAP) called Vibrio outer protein E (VopE) was identified… read more here.
Keywords: structure; gtpase activating; vope; activating protein ... See more keywords
The role of GTPase-activating protein ARHGAP26 in human cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04274-3
Abstract: Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho… read more here.
Keywords: role; protein arhgap26; gtpase activating; activating protein ... See more keywords
Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04039
Abstract: Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), which are endowed with beneficial biological activities as they reduce inflammation, regulate endothelial tone, improve mitochondrial function, and decrease oxidative stress. Therefore, inhibition of sEH for maintaining… read more here.
Keywords: seh; inhibition; lipoxygenase activating; soluble epoxide ... See more keywords
T‐cell activation RhoGTPase‐activating protein plays an important role in TH17‐cell differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.27
Abstract: T‐cell activation RhoGTPase‐activating protein (TAGAP) is a GTPase‐activating protein specific for RhoA that is exclusively expressed in activated T cells. Genome‐wide association studies and metagenome SNPs analyses have indicated that TAGAP is associated with the… read more here.
Keywords: th17; tagap; activating protein; differentiation ... See more keywords
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12544-4
Abstract: Immunotherapy involving checkpoint blockades of inhibitory co-receptors is effective in combating cancer. Despite this, the full range of mediators that inhibit T-cell activation and influence anti-tumor immunity is unclear. Here, we identify the GTPase-activating protein… read more here.
Keywords: tumor immunity; gtpase activating; activating protein; cell ... See more keywords
Affibody-targeted fluorogen activating protein for in vivo tumor imaging.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09137g
Abstract: Molecular imaging using near-infrared (NIR) fluorescence is useful for intraoperative imaging and real-time margin identification. Directly conjugated IR dyes possess useful properties for in vivo imaging, but conjugation often substantially alters the circulation dynamics of… read more here.
Keywords: affibody targeted; activating protein; fluorogen activating; tumor ... See more keywords
Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-01-0074
Abstract: In vivo and in vitro analyses reveal how a Cdc42 GTPase-activating protein (GAP) interacts with other negative polarity cues at old division sites in budding yeast. Mathematical modeling suggests that spatial distribution of a Cdc42… read more here.
Keywords: cdc42 gtpase; fine tuning; gtpase activating; tuning orientation ... See more keywords
IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz077
Abstract: Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory disease. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffold… read more here.
Keywords: lung ilc2s; containing gtpase; gtpase activating; ilc2s ... See more keywords
Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5‐Lipoxygenase Activating Protein Inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Science"
DOI: 10.1111/cts.12546
Abstract: We evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD5718, a novel 5‐lipooxygenase activating protein (FLAP) inhibitor, in a randomized, single‐blind, placebo‐controlled, first‐in‐human (FIH) study consisting of single and multiple ascending dosing (SAD and MAD) for… read more here.
Keywords: inhibitor; azd5718 novel; activating protein; initial clinical ... See more keywords
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317705769
Abstract: IQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway. However, the biological function and mechanism of IQ-domain GTPase-activating protein 1… read more here.
Keywords: invasive ductal; gtpase activating; activating protein; domain gtpase ... See more keywords