Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2522
Abstract: The participation of activating transcription factor 3 (ATF3) in transient middle cerebral artery occlusion and reperfusion injury has been reported. However, the precise mechanism of ATF3 in cerebral ischemia is little known so far. Thus,… read more here.
Keywords: cerebral ischemia; protective role; activating transcription; transcription factor ... See more keywords
Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93663-1
Abstract: The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized… read more here.
Keywords: adaptation human; transcription factor; activating transcription; glioblastoma cells ... See more keywords
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurotrauma"
DOI: 10.1089/neu.2015.3993
Abstract: The endoplasmic reticulum stress response (ERSR) is activated in a variety of neurodegenerative diseases and/or traumatic injuries. Subsequent restoration of ER homeostasis may contribute to improvement in the functional outcome of these diseases. We recently… read more here.
Keywords: endoplasmic reticulum; reticulum stress; stress response; activating transcription ... See more keywords
Activating transcription factor 5 (ATF5) promotes tumorigenic capability and activates the Wnt/b-catenin pathway in bladder cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02315-x
Abstract: Background In bladder cancer, up to 70% of patients will relapse after resection within 5 years, in which the mechanism underlying the recurrence remains largely unclear. Methods Quantitative real-time PCR, western blot and immunohistochemistry were conducted.… read more here.
Keywords: cancer; transcription factor; bladder cancer; bladder ... See more keywords
New Synthesized Activating Transcription Factor 3 Inducer SW20.1 Suppresses Resistin-Induced Metabolic Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11061509
Abstract: Obesity is an emerging concern globally with increasing prevalence. Obesity is associated with many diseases, such as cardiovascular disease, dyslipidemia, and cancer. Thus, effective new antiobesity drugs should be urgently developed. We synthesized SW20.1, a… read more here.
Keywords: sw20; transcription factor; resistin; activating transcription ... See more keywords
Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168890
Abstract: Neovascular age-related macular degeneration (nAMD) featuring choroidal neovascularization (CNV) is the principal cause of irreversible blindness in elderly people in the world. Integrated stress response (ISR) is one of the intracellular signals to be adapted… read more here.
Keywords: transcription factor; factor; choroidal neovascularization; activating transcription ... See more keywords
Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8451
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to adapt… read more here.
Keywords: hypoxia inducible; acute hypoxia; hypoxia; factor ... See more keywords
Activating transcription factor 3 enhances chemosensitivity of dichloroacetic acid via p53 pathway in cervical squamous epithelial cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v17i12.12
Abstract: Purpose: To investigate the effect of activating transcription factor 3 (ATF) on dichloroacetic acid (DCA) for the treatment of cervical cancer. Methods: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry assays were first used to determine… read more here.
Keywords: cancer; activating transcription; p53; transcription factor ... See more keywords