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   Articles with "activation" as a keyword



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Assessment of Trauma Team Activation Fees by US Region and Hospital Ownership.

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recommendations! Published in 2023 at "JAMA network open"

DOI: 10.1001/jamanetworkopen.2022.52520

Abstract: Importance Trauma centers must be readily equipped to handle a variety of life-threatening injuries and consequently may charge a fee for the activation of their trauma team. Regional and hospital-related variations in trauma activation fees… read more here.

Keywords: trauma activation; hospital; activation fees; trauma centers ... See more keywords
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Semen exosomes inhibit HIV infection and HIV‐induced proinflammatory cytokine production independent of the activation state of primary lymphocytes

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recommendations! Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13653

Abstract: Semen exosomes (SE) inhibit HIV infection. However, the effect of SE on cell activation and inflammation remains unknown. We characterized the response of peripheral blood mononuclear cells (PBMCs) from HIV‐uninfected and antiretroviral therapy‐suppressed HIV‐infected (HIV+)… read more here.

Keywords: hiv infection; semen exosomes; exosomes inhibit; hiv ... See more keywords
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Activation of P2X4 receptors induces an increase in the area of the extracellular region and a decrease in receptor mobility

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13942

Abstract: The P2X4 receptor (P2X4R) is an ATP‐gated cation channel. Here, we used fast‐scan atomic force microscopy (AFM) to visualize changes in the structure and mobility of individual P2X4Rs in response to activation. P2X4Rs were purified… read more here.

Keywords: extracellular region; mobility; activation; area extracellular ... See more keywords
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Site‐specific functional roles of the Factor X activation peptide in the intrinsic tenase‐mediated Factor X activation

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14321

Abstract: The conversion of zymogen Factor X (FX) to an active protease involves the removal of a 52‐residue long activation peptide (AP). Through site‐directed mutagenesis, we investigate the role of the AP and demonstrate that the… read more here.

Keywords: intrinsic tenase; factor activation; factor; site ... See more keywords
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Dynamical activation of function in metalloenzymes

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14515

Abstract: Formulations of hydrogen tunneling in enzyme‐catalysed C–H activation reactions indicate enthalpic barriers to reaction that are independent of chemical steps and dependent on the protein scaffold. A tool to identify catalytically relevant site‐specific protein thermal… read more here.

Keywords: activation function; thermal networks; function metalloenzymes; protein ... See more keywords
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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.

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recommendations! Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14675

Abstract: The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug… read more here.

Keywords: fgfr inhibitor; dna binding; hmga2; inhibitor pd173074 ... See more keywords
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MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701

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recommendations! Published in 2017 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12102

Abstract: Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors.… read more here.

Keywords: erk; mek inhibitors; akt activation; activation ... See more keywords
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Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12552

Abstract: Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an… read more here.

Keywords: colorectal cancer; hyper activation; activation; cancer cells ... See more keywords
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Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.

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recommendations! Published in 2023 at "Molecular oncology"

DOI: 10.1002/1878-0261.13454

Abstract: Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model of murine mammary gland tumors, Snai1… read more here.

Keywords: cafs; polarization; cancer associated; tumor ... See more keywords
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TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12195

Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.

Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords
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Estrogen inhibits starvation‐induced apoptosis in osteocytes by a redox‐independent process involving association of JNK and glutathione S‐transferase P1‐1

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12216

Abstract: Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress‐induced apoptosis, c‐Jun N‐terminal kinase (JNK) activation, and expression of factors involved in bone remodeling has… read more here.

Keywords: starvation induced; apoptosis; jnk; induced apoptosis ... See more keywords