Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.09.020
Abstract: The aims of the present study were to investigate the signaling mechanisms for sphingosine-1-phosphate (S1P)-induced airway smooth muscle cells (ASMCs) proliferation and to explore the effect of activation of adenosine monophosphate-activated protein kinase (AMPK) on… read more here.
Keywords: activation ampk; s1p induced; activation; asmcs proliferation ... See more keywords
Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134762
Abstract: Rab11, a small GTPase, is an important protein in the regulation of intracellular plasma membrane trafficking. Schwann cells are the main cells of peripheral nerves and knockdown of Rab11 in these cells inhibits the formation… read more here.
Keywords: glut1 glut3; cell proliferation; activation ampk; cell ... See more keywords
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.12.019
Abstract: Abstract Emerging evidence has shown that berberine has a protective effect against metabolic syndrome such as obesity and type II diabetes mellitus by activating AMP‐activated protein kinase (AMPK). AMPK induces CD36 trafficking to the sarcolemma… read more here.
Keywords: lipid accumulation; activation ampk; fatty acid; cd36 ... See more keywords
Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2126789
Abstract: Abstract Background The pathogenesis of peritoneal dialysis (PD)-related peritoneal fibrosis (PF) is not clearly understood, and current treatment options are limited. Methods In this study, the effect of PD-related PF on mitochondrial biogenesis was investigated,… read more here.
Keywords: mitochondrial biogenesis; ampk pgc; pgc pathway; activation ampk ... See more keywords
Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy245
Abstract: Myotonic dystrophy type 1 (DM1) is a debilitating multisystemic disorder caused by a triplet repeat expansion in the 3' untranslated region of dystrophia myotonica protein kinase mRNAs. Mutant mRNAs accumulate in the nucleus of affected… read more here.
Keywords: dm1 mouse; ampk; activation ampk; dm1 ... See more keywords
Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13046
Abstract: Although our recent study has demonstrated that mitotic spindle assembly checkpoint protein (MAD2B) mediates high glucose‐induced neuronal apoptosis, the mechanisms for MAD2B degradation under hyperglycaemia have not yet been elucidated. In this study, we first… read more here.
Keywords: degradation; mad2b; activation ampk; high glucose ... See more keywords
AICAR-induced activation of AMPK inhibits the migration of TSCC cells by targeting ZO-1.
Sign Up to like & getrecommendations! Published in 2019 at "Oral diseases"
DOI: 10.1111/odi.13212
Abstract: OBJECTIVE To investigate the effect of AMPK on tight junction (TJ) components, ZO-1 and F-actin, and the underlying mechanisms of AMPK in inhibiting migration of tongue squamous cell carcinoma (TSCC) cells. METHODS Expression and distribution… read more here.
Keywords: migration; activation ampk; activation; tscc cells ... See more keywords
No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Vascular Research"
DOI: 10.1159/000489959
Abstract: Background: Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes. Methods: Mice with constitutive endothelial activation of AMPK (CA-AMPK) were given a high fat… read more here.
Keywords: activation ampk; weight loss; renal arteries; activation ... See more keywords
Activation of AMPK by OSU53 protects spinal cord neurons from oxidative stress
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22055
Abstract: The present study tested the potential effect of OSU53, a novel AMPK activator, against hydrogen peroxide (H2O2)-induced spinal cord neuron damages. Treatment with OSU53 attenuated H2O2-induced death and apoptosis of primary murine spinal cord neurons.… read more here.
Keywords: osu53; cord; activation ampk; cord neurons ... See more keywords