Rh(III)-Catalyzed C-H Activation/[3 + 2] Annulation of N-Phenoxyacetamides via Carbooxygenation of 1,3-Dienes.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00945
Abstract: A unique Rh(III)-catalyzed C-H activation/[3 + 2] annulation of N-phenoxyacetamides has been developed for the construction of dihydrobenzofurans via carbooxygenation of 1,3-dienes. This transformation features a redox-neutral process with specific chemoselectivity, good substrate/functional group compatibility,… read more here.
Keywords: carbooxygenation dienes; iii catalyzed; catalyzed activation; activation annulation ... See more keywords
Rhodium-Catalyzed Selective C(sp2)-H Activation/Annulation of tert-Butyl Benzoyloxycarbamates with 1,3-Diynes: A One Step Access to Alkynylated Isocoumarins and Bis-Isocoumarins.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01901
Abstract: We report here a Rh(III) catalyzed regio- and stereoselective synthesis of alkynylated and bis-isocoumarin from 1,3-dialkyne. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers has been achieved by eliminating several other possibilities. This is the first example… read more here.
Keywords: bis isocoumarin; selective sp2; rhodium catalyzed; sp2 activation ... See more keywords
Cascade C-H Activation/Annulation of Sulfoxonium Ylides with Vinyl Cyclopropanes: Access to Cyclopropane-Fused α-Tetralones.
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DOI: 10.1021/acs.orglett.3c00650
Abstract: Rh-catalyzed weak and traceless directing-group-assisted cascade C-H activation and annulation of sulfoxonium ylides with vinyl cyclopropanes as a coupling partner have been accomplished to furnish functionalized cyclopropane-fused tetralones at moderate temperature. The C-C bond formation,… read more here.
Keywords: annulation sulfoxonium; vinyl cyclopropanes; cascade activation; ylides vinyl ... See more keywords
Construction of Peptide-Isoquinolone Conjugates via Rh(III)-Catalyzed C-H Activation/Annulation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00766
Abstract: Herein, we disclose a Rh(III)-catalyzed C-H activation/annulation reaction for the derivatization of Lys-based peptides, in situ affording diverse peptide-isoquinolone conjugates. This approach features racemization-free conditions, high atom- and step-economy, excellent chemo- and site-selectivity, and broad… read more here.
Keywords: isoquinolone; peptide isoquinolone; catalyzed activation; isoquinolone conjugates ... See more keywords
Expeditious synthesis of pyrano[2,3,4-de]quinolines via Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinolin-4-ol with alkynes.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04113f
Abstract: Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinoline-4-ols and alkynes has been reported. A broad range of tetracyclic pyrano[2,3,4-de]quinolines have been prepared in one-step with good functional group tolerance, excellent site selectivity, and high efficiency. read more here.
Keywords: annulation lactonization; iii catalyzed; cascade activation; pyrano quinolines ... See more keywords
Cascade intramolecular imidoylation and C-H activation/annulation of benzimidoyl chlorides with alkynes: one-pot synthesis of 7H-dibenzo[de,h]quinoline analogues.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03400e
Abstract: Reported herein is a cascade Lewis acid-promoted intramolecular Friedel-Crafts-type imidoylation and Rh(iii)-catalyzed C-H activation/annulation of benzimidoyl chlorides and alkynes, providing a general and concise one-pot approach to 7H-dibenzo[de,h]quinoline analogues. This divergent approach is based on… read more here.
Keywords: annulation benzimidoyl; dibenzo quinoline; chlorides alkynes; activation annulation ... See more keywords
A Ru(II)-Catalyzed C–H Activation and Annulation Cascade for the Construction of Highly Coumarin-fused Benzo[a]quinolizin-4-ones and Pyridin-2-ones
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00255a
Abstract: A Ru(II)-catalyzed C–H activation and annulation cascade were successfully established for the constructions of coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones, in which the intriguing 6-6-6-6-6 pentacyclic coumarin-fused scaffold was formed by a... read more here.
Keywords: annulation cascade; fused benzo; catalyzed activation; coumarin fused ... See more keywords
Practical synthesis of isocoumarins via Rh(III)-catalyzed C–H activation/annulation cascade
Sign Up to like & getrecommendations! Published in 2023 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.19.10
Abstract: Herein, we report an unprecedented Rh(III)-catalyzed C–H activation/annulation cascade of readily available enaminones with iodonium ylides towards the convenient synthesis of isocoumarins. This coupling system proceeds in useful chemical yields (up to 93%) via a… read more here.
Keywords: annulation cascade; annulation; catalyzed activation; activation annulation ... See more keywords