3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.08.007
Abstract: Acute lymphoblastic leukemia (ALL) samples exhibit an activated PI3K/Akt pathway, which suggests a general role of Akt in the development of leukemia. We have previously used western blot analysis to show that the catalytic topoisomerase… read more here.
Keywords: 3ez 20ac; apoptosis; activation atr; cyclin ... See more keywords
Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14120
Abstract: Primary infection of the immunocompromised host with the oncovirus Epstein-Barr virus (EBV) that targets mainly B-cells is associated with an increased risk for EBV-associated tumors. The early events subsequent to primary infection with potential for… read more here.
Keywords: tonsillar cells; atr chk1; activation atr; infection ... See more keywords