Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling
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DOI: 10.1038/s41598-017-09045-z
Abstract: Autophagy serves as a protective mechanism to degrade damaged organelles and proteins. Acute alcohol exposure is known to activate the hepatic autophagy response, whereas chronic alcohol exposure slows autophagosome formation along with an elevation of… read more here.
Keywords: etoh lps; activation autophagy; lps induced; activation ... See more keywords
ASIC1a involves acidic microenvironment-induced activation and autophagy of pancreatic stellate cells
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DOI: 10.1039/c8ra03679a
Abstract: Acid-sensing ion channel 1a (ASIC1a), as a member of the proton-gated cation channel family, can be activated by low extracellular pH, and takes part in many acidity-associated physiopathological processes. However, whether ASIC1a is expressed in… read more here.
Keywords: activation autophagy; pscs; asic1a; pancreatic stellate ... See more keywords
Activation of autophagy inhibits NLRP3 inflammasome activation and attenuates myocardial ischemia-reperfusion injury in diabetic rats.
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DOI: 10.1111/jdi.13235
Abstract: BACKGROUND Diabetic hearts are more vulnerable to ischemia/reperfusion injury (I/RI). The activation of NLRP3 inflammasome can mediate inflammatory process, and hence may contribute to myocardial I/RI. Activation of autophagy can eliminate excess ROS and alleviate… read more here.
Keywords: activation autophagy; activation; nlrp3 inflammasome; ischemia reperfusion ... See more keywords
Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy
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DOI: 10.1155/2019/8187529
Abstract: Heat stroke (HS) is a life-threatening illness and defined as when body temperature elevates above 40°C accompanied by the systemic inflammatory response syndrome that results in multiple organ dysfunctions. α-Lipoic acid (ALA) acts as a… read more here.
Keywords: activation autophagy; inflammatory; heat stroke; heat ... See more keywords