NRF2 Activation in Cancer: From DNA to Protein.
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DOI: 10.1158/0008-5472.can-18-2723
Abstract: The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated protein 1 and nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway in 6.3% of patient samples across 226 studies, with significant enrichment in lung… read more here.
Keywords: activation cancer; nrf2 activation; cancer dna; cancer ... See more keywords
Abstract 4743: Inhibition of the Hif1a-mediated checkpoint refuels NK activation in cancer
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DOI: 10.1158/1538-7445.am2018-4743
Abstract: Solid tumors remain a major challenge for immunotherapy of cancer due to their immunosuppressive microenvironment. Hypoxia is a common feature of solid tumors and might affect immune cell activation within the tumor tissue. Upon hypoxia… read more here.
Keywords: activation cancer; cancer; cell; hif1a ... See more keywords