Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03933-4
Abstract: Graphic abstract The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Ca2+ store depletion triggers conformational changes… read more here.
Keywords: orai1; stim1; ca2; activation ... See more keywords
Nosema bombycis suppresses host hemolymph melanization through secreted serpin 6 inhibiting the prophenoloxidase activation cascade.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of invertebrate pathology"
DOI: 10.1016/j.jip.2019.107260
Abstract: Nosema bombycis is a pathogen of the silkworm that belongs to the microsporidia, a group of obligate intracellular parasites related to fungi. N. bombycis infection causes the disease pébrine in silkworms. Insects utilize hemolymph melanization… read more here.
Keywords: bombycis; melanization; hemolymph melanization; host ... See more keywords