TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma cells via activation of β-catenin
Sign Up to like & getrecommendations! Published in 2019 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-019-0421-7
Abstract: Metastasis is one of the main contributors to the poor prognosis of hepatocellular carcinoma (HCC). However, the underlying mechanism of HCC metastasis remains largely unknown. Here, we showed that TXNDC12, a thioredoxin-like protein, was upregulated… read more here.
Keywords: hepatocellular carcinoma; catenin; metastasis; activation catenin ... See more keywords
Abstract 2559: Loss of AKT2 correlates with activation of β-catenin signaling in immortalized mouse hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2559
Abstract: Background: Primary liver cancer is the second most common cause of cancer-related mortality. Abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/AKT and Wnt/β-catenin signaling pathways, which act as key regulators in cell proliferation and growth, is… read more here.
Keywords: activation catenin; akt2; catenin signaling; catenin ... See more keywords
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000492549
Abstract: Background/Aims: Activation of the Wnt/β-catenin signalling pathway has been widely investigated in bone biology and shown to promote bone formation. However, its specific effects on osteoclast differentiation have not been fully elucidated. Our study aimed… read more here.
Keywords: catenin; activation catenin; bone; constitutive activation ... See more keywords
HSP27 promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP3 pathway in pancreatic ductal adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/31074
Abstract: Background: The precise role of heat shock protein 27 (HSP27), as a type of small molecular protein in HSPs, in pancreatic ductal adenocarcinoma (PDAC) remains to be elucidated. The aim of the present study was… read more here.
Keywords: hsp27; pdac; activation catenin; pancreatic ductal ... See more keywords