Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells.
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DOI: 10.1111/1759-7714.14400
Abstract: BACKGROUND Radiotherapy is an effective therapeutic approach widely used clinically in non-small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA-sensing… read more here.
Keywords: sting pathway; cgas sting; activation cgas; increased activation ... See more keywords
DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling
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DOI: 10.3389/fcell.2021.828657
Abstract: DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses. The cGAS/STING pathway has been investigated as a critical receptor in both exogenous… read more here.
Keywords: dna damage; sting pathway; cgas sting; activation cgas ... See more keywords