Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic cancer"
DOI: 10.1111/1759-7714.14400
Abstract: BACKGROUND Radiotherapy is an effective therapeutic approach widely used clinically in non-small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA-sensing… read more here.
Keywords: sting pathway; cgas sting; activation cgas; increased activation ... See more keywords
Abstract 7460: Characterizing the role of PCBP1 in the activation of the cGAS-STING/type I Interferon axis to promote anti-tumor immunity
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DOI: 10.1158/1538-7445.am2024-7460
Abstract: The emergence of immunotherapies has encouraged the need to better understand the molecular mechanisms that modulate the tumor immune microenvironment to kill cancer cells as well as the strategies used by cancer cells to evade… read more here.
Keywords: cancer; activation cgas; pcbp1; tumor ... See more keywords
DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling
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DOI: 10.3389/fcell.2021.828657
Abstract: DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses. The cGAS/STING pathway has been investigated as a critical receptor in both exogenous… read more here.
Keywords: dna damage; sting pathway; cgas sting; activation cgas ... See more keywords