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   Articles with "activation dynamics" as a keyword



Insights into Ligand-Specific Activation Dynamics of Dopamine D2 Receptor Explored by MD Simulations

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recommendations! Published in 2025 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.4c02101

Abstract: The human G protein-coupled receptor (GPCR) dopamine 2 receptor (D2R) is an essential target of antipsychotic drugs. The modulation of downstream GPCR signaling induced by different agonists, termed functional selectivity, has potentially a great impact… read more here.

Keywords: receptor; activation dynamics; dopamine receptor; ligand specific ... See more keywords

Activation dynamics of ubiquitin-specific protease 7

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2426632122

Abstract: Significance Ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme linked to cancers and neurodevelopmental disorders, adopts an inactive ground conformation and requires substrate binding for activation. Using NMR and enzyme kinetic analyses, we unravel the enzyme… read more here.

Keywords: dynamics ubiquitin; activation dynamics; activation; ubiquitin specific ... See more keywords

Activation dynamics traced through a G protein-coupled receptor by 81 1H-15N NMR probes.

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recommendations! Published in 2025 at "Science"

DOI: 10.1126/science.adq9106

Abstract: The regulation of G protein-coupled receptor signaling by different orthosteric ligands is thought to occur through shifts in dynamically interconverting, conformational distributions. Such changes in dynamical distributions have been detected so far only by very… read more here.

Keywords: receptor; activation dynamics; coupled receptor; protein coupled ... See more keywords
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Identification of molecular determinants that govern distinct STIM2 activation dynamics

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recommendations! Published in 2018 at "PLoS Biology"

DOI: 10.1371/journal.pbio.2006898

Abstract: The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the… read more here.

Keywords: stim2; activation dynamics; stim2 activation; identification molecular ... See more keywords