The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.015
Abstract: We previously reported that the Bcl-2 family member human Bcl-rambo, also known as BCL2L13, induces apoptosis in human embryonic kidney 293T cells. Mouse Bcl-rambo has recently been reported to mediate mitochondrial fragmentation and mitophagy. In… read more here.
Keywords: effector caspases; bcl rambo; activation effector; human bcl ... See more keywords
Abstract 4156: Differential effects of tumor metabolites on T cell activation and effector function
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DOI: 10.1158/1538-7445.am2025-4156
Abstract: Over the past decade, immunotherapies have significantly improved clinical outcomes in cancer patients. The FDA approval of ICB for cancer treatment represents a clinical milestone, however, durable responses are observed in only ∼20-40% of patients.… read more here.
Keywords: activation effector; tumor; effector function; activation ... See more keywords