Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000489757
Abstract: Background/Aims: Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy. However, the role… read more here.
Keywords: doca salt; socs3; salt induced; activation gp130 ... See more keywords
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200788
Abstract: IL-6 family members contribute to host defense through the stimulation of acute-phase signaling, hematopoiesis, immune reactions, and regenerative processes. To investigate essential mechanisms that are linked toward a constitutively activated gp130 signaling, we generated and… read more here.
Keywords: cell; gp130 cells; activation gp130; gp130 ... See more keywords