PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix
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DOI: 10.1016/j.isci.2018.06.012
Abstract: Summary Peroxisome proliferator activated receptor γ (PPARγ) is a nuclear receptor and target for antidiabetics that increase insulin sensitivity. Owing to the side effects of PPARγ full agonists, research has recently focused on non-activating ligands… read more here.
Keywords: ppar; inverse agonist; activation helix; helix ... See more keywords