Inflammasome Activation in Human Macrophages Induced by a LDL (−) Mimetic Peptide
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01159-y
Abstract: The inflammasome is responsible for maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18) contributing to the inflammatory process in atherosclerosis. It is shown here that an electronegative low-density lipoprotein [LDL (−)] apoB-100 mimetic peptide can activate… read more here.
Keywords: inflammasome activation; activation human; activation; mimetic peptide ... See more keywords
The influences of α-hemolytic Streptococcus on class switching and complement activation of human tonsillar cells in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Immunologic research"
DOI: 10.1007/s12026-021-09223-2
Abstract: While β-hemolytic streptococcus (β-HS) infections are known to predispose patients to acute poststreptococcal glomerulonephritis, there is evidence that implicates α-hemolytic streptococcus (α-HS) in IgA nephropathy (IgAN). The alternative pathway of the complement system has also… read more here.
Keywords: iga nephropathy; activation human; hemolytic streptococcus; complement activation ... See more keywords
Inhibitory effect of porphyran on lipopolysaccharide-induced activation of human immune cells.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115811
Abstract: In mice, porphyran extracted from Pyropia yezoensis exerts anti-inflammatory effects and suppresses lipopolysaccharide (LPS)-induced immune activation and sepsis. Here, we investigated inhibition of LPS-induced activation of human immune cells by porphyran and the underlying mechanisms.… read more here.
Keywords: lps induced; porphyran; activation human; human immune ... See more keywords
Dothiorelone derivatives from an endophyte Diaporthe pseudomangiferaea inhibit the activation of human lung fibroblasts MRC-5 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Fitoterapia"
DOI: 10.1016/j.fitote.2018.04.009
Abstract: Nine new compounds (1-6 and 16-18) and nine known compounds (7-15) were isolated from Diaporthe pseudomangiferaea, an endophytic fungus obtained from the leaves of the toxic Chinese folk medicine Tylophora ouata. Their structures were elucidated… read more here.
Keywords: lung fibroblasts; activation human; fibroblasts mrc; mrc cells ... See more keywords
Activation of human monocytes by colloidal aluminium salts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.08.014
Abstract: Subunit vaccines often contain colloidal aluminium salt-based adjuvants to activate the innate immune system. These aluminium salts consist of micrometre-sized aggregates. It is well known that particle size affects the adjuvant effect of particulate adjuvants.… read more here.
Keywords: colloidal aluminium; aluminium; human monocytes; activation human ... See more keywords
Fcγ Receptor Activation by Human Monoclonal Antibody Aggregates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.10.046
Abstract: Protein aggregates are a potential risk factor for immunogenicity. The measurement, characterization, and control of protein aggregates in drug products are indispensable for the development of biopharmaceuticals, including therapeutic monoclonal antibodies (mAbs). In this study,… read more here.
Keywords: receptor activation; activation human; mab aggregates; activation ... See more keywords
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy263
Abstract: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon receptor (Ahr) in rodents. However, the carcinogenic effect of TCDD and AHR in humans has been controversial.… read more here.
Keywords: ahr; activation human; human ahr; constitutive activation ... See more keywords
Low-Dose Dose–Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Dose-Response"
DOI: 10.1177/1559325817699696
Abstract: Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeostasis, cytoprotective responses,… read more here.
Keywords: dose response; response; vitro nrf2; activation human ... See more keywords
Activation of human macrophages by human corneal allogen in vitro
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0194855
Abstract: Purpose To study distinct aspects of human monocyte-derived macrophage (MDM) activation by human corneal tissue as a possible initial stage in human corneal allograft rejection. Methods Human monocytes were isolated from peripheral blood mononuclear cells… read more here.
Keywords: corneal; activation human; human corneal; human macrophages ... See more keywords
Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.839249
Abstract: Voltage-gated potassium channels of the Kv7.x family are involved in a plethora of biological processes across many tissues in animals, and their misfunctioning could lead to several pathologies ranging from diseases caused by neuronal hyperexcitability,… read more here.
Keywords: binding activation; insights binding; molecular insights; activation human ... See more keywords
Superantigenic Activation of Human Cardiac Mast Cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20081828
Abstract: B cell superantigens, also called immunoglobulin superantigens, bind to the variable regions of either the heavy or light chain of immunoglobulins mirroring the lymphocyte-activating properties of classical T cell superantigens. Protein A of Staphylococcus aureus,… read more here.
Keywords: cardiac mast; mast cells; mast; immunoglobulin superantigens ... See more keywords