Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions.
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DOI: 10.1021/acs.bioconjchem.1c00276
Abstract: Strained alkenes and alkynes are the predominant dienophiles used in inverse electron demand Diels-Alder (IEDDA) reactions. However, their instability, cross-reactivity, and accessibility are problematic. Unstrained dienophiles, although physiologically stable and synthetically accessible, react with tetrazines… read more here.
Keywords: iedda reactions; arylethynyltrifluoroborate dienophiles; activation iedda; dienophiles demand ... See more keywords