DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.085
Abstract: The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG… read more here.
Keywords: ddx6; activation; stimulated genes; interferon stimulated ... See more keywords
MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2024 at "Immunological Investigations"
DOI: 10.1080/08820139.2023.2300346
Abstract: ABSTRACT MicroRNA-98-5p (miR-98-5p) plays a protective role in the pathogenesis of autoimmune diseases through anti-inflammatory effects, but little is known about its role in Systemic lupus erythematosus (SLE). Our previous study suggested Interferon-inducible 44 like… read more here.
Keywords: ifi44l; systemic lupus; activation interferon; dendritic cells ... See more keywords
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abf8627
Abstract: Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3–9 homolog 1 (SUV39H1) is required for… read more here.
Keywords: cells activation; activation interferon; interferon pathway; pathway ... See more keywords