DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.085
Abstract: The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG… read more here.
Keywords: ddx6; activation; stimulated genes; interferon stimulated ... See more keywords
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abf8627
Abstract: Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3–9 homolog 1 (SUV39H1) is required for… read more here.
Keywords: cells activation; activation interferon; interferon pathway; pathway ... See more keywords