Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
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DOI: 10.1021/acs.molpharmaceut.2c00540
Abstract: The mechanistic details behind the activation of lecithin-cholesterol acyltransferase (LCAT) by apolipoprotein A-I (apoA-I) and its mimetic peptides are still enigmatic. Resolving the fundamental principles behind the LCAT activation will facilitate the design of advanced… read more here.
Keywords: activation lecithin; lcat; lecithin cholesterol; cholesterol acyltransferase ... See more keywords